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Bespoke Bioprinting

It's Alive! Revolutionizing Bioprinting with Personalized Tissues

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Engineered advanced 3D microfluidic alveoli with unparalleled precision
Demonstrated the potential for patient-specific drug testing and organ production
Pioneered a scalable, algorithmic engineering approach for bio-inspired tissue design

The Challenge

In the face of escalating demands for precise, customizable healthcare solutions, our partnership aimed to transcend traditional bioprinting limitations. The endeavor focused on crafting alveoli models that mirror human lung tissues, challenging due to the complex interplay of vascular systems and extracellular matrices. This project sought not only to enhance drug testing accuracy but also to pave the way for creating organs tailored to individual immune systems.

The Process

Leveraging Hyperganic Core, we introduced an innovative algorithmic engineering approach, generating biomimetic alveoli structures with unmatched detail and variability. This method, inspired by natural growth patterns, allowed for rapid iteration of designs, including diverse alveolar shapes and vascular networks. By simulating biological randomness, we achieved organotypical geometries that traditional CAD tools could not replicate, facilitating a significant leap in bioprinting research and application.

The Results

The collaboration resulted in the bioprinting of polymer and proteinaceous resin alveoli, showcasing extraordinary detail even at micro scales. This breakthrough not only underscores the feasibility of printing and studying complex tissue structures but also marks a critical step towards customizing healthcare. With Hyperganic’s algorithmic engineering, we envision a future where bioprinted organs are tailored to individual needs, drastically reducing the reliance on animal testing and revolutionizing personalized medicine.

Printed in resin

“While using CAD tools, I often struggled to design organotypical bioprinting templates. Considering the lengthy process of modeling alveoli in CAD, I was surprised by how quickly and effortlessly Hyperganic Core had allowed me to create not only one but a limitless variety of these biomimetic scaffolds. This was especially true for the generation of interconnected vascular networks, which are automatically adjusted to the tissue to be perfused, enabling us to perform extensive research on angiogenesis.”

Amelie Erben, PhD
Researcher & PhD Candidate
Center for Applied Tissue Engineering and Regenerative Medicine, TUM Graduate School

Printed in Bio-ink

This collaboration represents a significant milestone, featuring our novel design approach in scientific literature and setting the stage for further advancements in bioprinting and regenerative medicine.